Description

6-(Trifluoromethyl)-2-Azaspiro[3.3]Heptan-6-Ol is a high-value, multifunctional spirocyclic building block featuring a trifluoromethyl group and a hydroxyl moiety. This compound is critical for medicinal chemistry and agrochemical research, where its unique three-dimensional structure and fluorine content are leveraged to modulate the physicochemical properties of target molecules. It is primarily sought after by pharmaceutical and agrochemical R&D teams for the synthesis of novel active ingredients, offering advantages in metabolic stability, lipophilicity, and bioavailability.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and antiviral therapeutic areas.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science Research: Serves as a precursor for specialty polymers and advanced materials requiring fluorinated components for specific performance characteristics.
• Ligand and Catalyst Development: Employed in the design of novel chiral ligands and organocatalysts for asymmetric synthesis.
• Chemical Biology Probes: Utilized as a scaffold for creating molecular probes to study enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up production under cGMP conditions for clinical trials.

Basic Information

Product Name	6-(Trifluoromethyl)-2-Azaspiro[3.3]Heptan-6-Ol
CAS No.	1251924-12-5
Molecular Formula	C8H10F3NO
Molecular Weight	193.17 g/mol
Synonyms	6-(Trifluoromethyl)-2-azaspiro[3.3]heptan-6-ol; 2-Azaspiro[3.3]heptan-6-ol, 6-(trifluoromethyl)-; 6-Trifluoromethyl-2-azaspiro[3.3]heptan-6-ol; 6-Hydroxy-6-(trifluoromethyl)-2-azaspiro[3.3]heptane; Trifluoromethyl Azaspiroheptanol; Azaspirocyclic Trifluoromethyl Alcohol; Spirocyclic CF3 Building Block
EINECS	Contact for details

Quality Control

Our 6-(Trifluoromethyl)-2-Azaspiro[3.3]Heptan-6-Ol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with detailed specifications for every shipment. Our quality commitment supports development from research to commercial scale, with documentation suitable for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.