Description

Cyclobutanepropanoic Acid, α-Amino-, Methyl Ester, (αs)- CAS NO 1251903-81-7 is a high-purity, non-natural amino acid derivative featuring a cyclobutane ring, a key structural motif in advanced organic synthesis. This compound serves as a critical chiral building block for the development of novel pharmaceuticals and bioactive molecules, offering precise stereochemical control. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, peptide mimetics, and the synthesis of complex active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in oncology and metabolic disease research.
• Peptidomimetics: Used to construct constrained peptide analogs and macrocycles to enhance metabolic stability and binding affinity.
• Chemical Biology Probes: Employed in the synthesis of labeled compounds and molecular probes for studying biological pathways and target engagement.
• Asymmetric Synthesis: Serves as a versatile starting material or intermediate in catalytic asymmetric reactions to introduce complex stereocenters.
• Agrochemical Research: Potential application in the design of novel, biologically active compounds for crop protection.
• Academic & Contract Research: Essential for fundamental organic chemistry research and custom synthesis projects in CROs (Contract Research Organizations).

Basic Information

Product Name	Cyclobutanepropanoic Acid, α-Amino-, Methyl Ester, (αs)-
CAS No.	1251903-81-7
Molecular Formula	C8H15NO2
Molecular Weight	157.21 g/mol
Synonyms	(αS)-α-Aminocyclobutanepropanoic Acid Methyl Ester; Methyl (S)-2-Amino-2-cyclobutylacetate; (S)-2-Amino-2-cyclobutylacetic Acid Methyl Ester; (S)-Methyl 2-Amino-2-cyclobutylacetate; Cyclobutanepropanoic acid, α-amino-, methyl ester, (αS)-; (S)-2-Cyclobutylglycine Methyl Ester; (S)-Methyl 2-Aminocyclobutanebutanoate; L-Cyclobutylglycine Methyl Ester
EINECS	Contact for details

Quality Control

Our production of Cyclobutanepropanoic Acid, α-Amino-, Methyl Ester, (αs)- adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure high chemical and enantiomeric purity suitable for sensitive pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.