Description

N,4-Dimethyl-n-[4-(Trimethylsilyl)Phenyl]Benzenesulfonamide is a specialized organosilicon-substituted sulfonamide compound designed for advanced synthetic chemistry. This high-purity intermediate is valued for its unique molecular architecture, which combines a sulfonamide moiety with a trimethylsilyl-protected aromatic system, offering distinct reactivity and stability profiles. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and advanced materials sectors for constructing complex molecules, including active pharmaceutical ingredients (APIs) and functional polymers.

Application

• As a key synthetic intermediate in the research and development of novel pharmaceutical compounds.
• For use in advanced organic synthesis, particularly in reactions requiring silicon-based protecting groups or directing moieties.
• In the preparation of functional materials and specialty polymers where the sulfonamide and silane groups impart specific properties.
• As a building block in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Potential use in the synthesis of liquid crystal precursors or electronic materials.
• For process chemistry scale-up in cGMP environments for API manufacturing.

Basic Information

Product Name	N,4-Dimethyl-n-[4-(Trimethylsilyl)Phenyl]Benzenesulfonamide
CAS No.	1251740-03-0
Molecular Formula	C17H23NO2SSi
Molecular Weight	333.53 g/mol
Synonyms	Benzenesulfonamide, N,4-dimethyl-N-[4-(trimethylsilyl)phenyl]-; 4-(Trimethylsilyl)-N-(4-methylphenyl)benzenesulfonamide; N,4-Dimethyl-N-(4-trimethylsilylphenyl)benzenesulfonamide; TMS-Protected Sulfonamide Intermediate; 4-Methyl-N-[4-(trimethylsilyl)phenyl]benzenesulfonamide
EINECS	Contact for details

Quality Control

Our N,4-Dimethyl-n-[4-(Trimethylsilyl)Phenyl]Benzenesulfonamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP and ISO 9001 standards where applicable, ensuring reliability for research and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.