Description

2-[(6-Chloro-2-Methyl-4-Pyrimidinyl)Amino]-5-Thiazolecarboxylic Acid Methyl Ester is a high-purity, advanced pharmaceutical intermediate with a CAS number of 1251716-80-9. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. It is essential for research institutions and pharmaceutical manufacturers engaged in the development of new drug candidates, agrochemicals, and specialized fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging its heterocyclic structure for biological activity.
• Chemical Biology & Proteomics: Serves as a valuable scaffold or linker in the design of chemical probes for studying biological pathways.
• Organic Synthesis: Employed in academic and industrial R&D for constructing complex molecules containing pyrimidine and thiazole motifs.
• Material Science Precursor: Potential use in the synthesis of organic electronic materials or metal-organic frameworks (MOFs).

Basic Information

Product Name	2-[(6-Chloro-2-Methyl-4-Pyrimidinyl)Amino]-5-Thiazolecarboxylic Acid Methyl Ester
CAS No.	1251716-80-9
Molecular Formula	C10H9ClN4O2S
Molecular Weight	284.72 g/mol
Synonyms	Methyl 2-[(6-chloro-2-methylpyrimidin-4-yl)amino]-1,3-thiazole-5-carboxylate; 2-((6-Chloro-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxylic acid methyl ester; 6-Chloro-2-methyl-N-(5-(methoxycarbonyl)thiazol-2-yl)pyrimidin-4-amine; UNII-9J8B5S8C3R; 9J8B5S8C3R; AKOS025310991; AS-76325; CHEMBL3185222
EINECS	Contact for details

Quality Control

Our 2-[(6-Chloro-2-Methyl-4-Pyrimidinyl)Amino]-5-Thiazolecarboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat and incompatible materials. The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.