Description

(2R)-2-[[(1,1-Dimethylethyl)Diphenylsilyl]Oxy]-5-(Trimethylsilyl)-4-Pentyn-1-Ol is a high-purity, chiral synthetic intermediate featuring dual silyl protecting groups, making it a critical building block for advanced organic synthesis. This compound is valued for its role in constructing complex molecular architectures with precise stereochemical control. It is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of active pharmaceutical ingredients (APIs) and other fine chemicals.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Agrochemical Research: Used in the development of novel pesticides and herbicides requiring specific stereochemistry.
• Organic Synthesis: Serves as a versatile building block in multi-step synthesis, particularly in reactions where the protection of alcohol and alkyne functionalities is required.
• Academic & Industrial R&D: Employed in research laboratories for methodological development and the construction of natural product analogs.
• Material Science Precursor: Potential use in the synthesis of specialized polymers or functionalized surfaces.

Basic Information

Product Name	(2R)-2-[[(1,1-Dimethylethyl)Diphenylsilyl]Oxy]-5-(Trimethylsilyl)-4-Pentyn-1-Ol
CAS No.	1251537-18-4
Molecular Formula	C24H34O2Si2
Molecular Weight	410.70 g/mol
Synonyms	(2R)-2-[(tert-Butyldiphenylsilyl)oxy]-5-(trimethylsilyl)-4-pentyn-1-ol; (R)-2-((tert-Butyldiphenylsilyl)oxy)-5-(trimethylsilyl)pent-4-yn-1-ol; (2R)-2-[(Tert-Butyldiphenylsilyl)oxy]-5-(trimethylsilyl)-4-pentyn-1-ol; TBDPS-protected chiral propargylic alcohol; (R)-TBDPSO-CH2C≡C-CH2-CH(OTBDPS)-? (Structural variant); Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our (2R)-2-[[(1,1-Dimethylethyl)Diphenylsilyl]Oxy]-5-(Trimethylsilyl)-4-Pentyn-1-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure high chemical and enantiomeric purity suitable for sensitive synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.