Description

(5S)-5-Hydroxy-6-Heptynoic Acid 1-Methylethyl Ester CAS NO 1251537-14-0 is a high-purity chiral building block and synthetic intermediate characterized by its terminal alkyne and protected hydroxyl functionalities. This compound is of significant value in advanced organic synthesis, particularly for constructing complex molecular architectures via click chemistry and cross-coupling reactions. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of prostaglandins, leukotriene analogs, and other bioactive molecules.
• Click Chemistry Reagent: Utilized in Huisgen cycloaddition reactions due to its terminal alkyne group, enabling efficient bioconjugation and polymer functionalization.
• Cross-Coupling Substrate: Serves as a coupling partner in Sonogashira, Glaser, and other palladium-catalyzed reactions to form carbon-carbon bonds.
• Asymmetric Synthesis: The (5S) stereocenter provides a handle for diastereoselective transformations in natural product and medicinal chemistry.
• Ligand and Catalyst Development: Used in the preparation of novel chiral ligands for asymmetric catalysis.
• Material Science Research: Employed in the synthesis of functionalized polymers and advanced organic materials.

Basic Information

Product Name	(5S)-5-Hydroxy-6-Heptynoic Acid 1-Methylethyl Ester
CAS No.	1251537-14-0
Molecular Formula	C11H16O3
Molecular Weight	196.24 g/mol
Synonyms	(5S)-5-Hydroxy-6-heptynoic acid isopropyl ester; Isopropyl (5S)-5-hydroxy-6-heptynoate; (S)-5-Hydroxy-6-heptynoic acid 1-methylethyl ester; (S)-Isopropyl 5-hydroxy-6-heptynoate; 6-Heptynoic acid, 5-hydroxy-, 1-methylethyl ester, (5S)-; A chiral heptynoate ester
EINECS	Contact for details

Quality Control

Our (5S)-5-Hydroxy-6-Heptynoic Acid 1-Methylethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to ensure high chemical and optical purity suitable for sensitive synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere for long-term storage to preserve stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.