Description

(3-Bromo-4-Fluoro-Phenyl)-Chloro-Acetic Acid Methyl Ester is a high-purity, multi-functional halogenated aromatic ester building block essential for advanced organic synthesis. This compound matters for its unique molecular architecture, which provides multiple reactive sites for constructing complex molecules with precise regiochemistry. Pharmaceutical, agrochemical, and advanced material researchers need it for developing novel active ingredients and specialty chemicals, leveraging its bromo, fluoro, and chloro substituents for targeted molecular modifications.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where its halogenated phenyl core contributes to biological activity and metabolic stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for synthesizing halogenated aromatic compounds used in electronic display materials and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) due to the presence of the bromo substituent.
• Functional Material Research: Employed in academic and industrial R&D for creating novel polymers, ligands, and specialty chemicals with tailored properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific halogenated intermediates.

Basic Information

Product Name	(3-Bromo-4-Fluoro-Phenyl)-Chloro-Acetic Acid Methyl Ester
CAS No.	1251208-19-1
Molecular Formula	C9H7BrClFO2
Molecular Weight	281.51 g/mol
Synonyms	Methyl (3-bromo-4-fluorophenyl)(chloro)acetate; Methyl 2-chloro-2-(3-bromo-4-fluorophenyl)acetate; 2-Chloro-2-(3-bromo-4-fluorophenyl)acetic acid methyl ester; (3-Bromo-4-fluorophenyl)(chloro)acetic acid methyl ester; Chloro(3-bromo-4-fluorophenyl)acetic acid methyl ester; α-Chloro-3-bromo-4-fluorophenylacetic acid methyl ester; CAS 1251208-19-1
EINECS	Contact for details

Quality Control

Our (3-Bromo-4-Fluoro-Phenyl)-Chloro-Acetic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications in regulated environments, and we can supply material tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container must be kept tightly sealed to prevent moisture absorption and potential decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.