Description

Methyl 7-Cyclopropyl-5-Oxo-4,5-Dihydrothieno[3,2-B]Pyridine-3-Carboxylate CAS NO 1251033-78-9 is a high-purity, advanced pharmaceutical intermediate with a complex fused heterocyclic structure. This compound is of significant value for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular scaffolds. It is primarily needed by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the discovery and development of new drugs.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders, inflammatory diseases, or oncology.
• Research & Development (R&D): Used in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization to develop new chemical entities.
• Active Pharmaceutical Ingredient (API) Synthesis: Incorporated into the final synthetic route for novel APIs that feature the thienopyridine core, a privileged structure in drug design.
• Contract Manufacturing: Supplied to CDMOs for scale-up and cGMP production of clinical trial materials and commercial APIs.
• Chemical Reference Standard: Can be utilized as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	Methyl 7-Cyclopropyl-5-Oxo-4,5-Dihydrothieno[3,2-B]Pyridine-3-Carboxylate
CAS No.	1251033-78-9
Molecular Formula	C12H11NO3S
Molecular Weight	249.29 g/mol
Synonyms	Methyl 7-cyclopropyl-5-oxo-4,5-dihydrothieno[3,2-b]pyridine-3-carboxylate; 7-Cyclopropyl-5-oxo-4,5-dihydrothieno[3,2-b]pyridine-3-carboxylic acid methyl ester; Thieno[3,2-b]pyridine-3-carboxylic acid, 7-cyclopropyl-4,5-dihydro-5-oxo-, methyl ester; Methyl 7-cyclopropyl-5-oxo-4,5-dihydrothieno[3,2-b]pyridine-3-carboxylate (CAS 1251033-78-9); 1251033-78-9
EINECS	Contact for details

Quality Control

Our Methyl 7-Cyclopropyl-5-Oxo-4,5-Dihydrothieno[3,2-B]Pyridine-3-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and manufacturing. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storage under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5% Total impurities ≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.