Description

Ethyl 5-Boc-5-Aza-Spiro[3.4]Octane-2-Carboxylate is a high-value, protected spirocyclic building block essential for modern pharmaceutical research and development. This compound serves as a critical intermediate in the synthesis of complex molecules, enabling the exploration of novel chemical space for drug discovery. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries to construct advanced scaffolds for potential therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs) targeting central nervous system (CNS) disorders, oncology, and other therapeutic areas.
• Medicinal Chemistry: Used for constructing spirocyclic and constrained analogs in structure-activity relationship (SAR) studies to optimize potency, selectivity, and pharmacokinetic properties.
• Process Chemistry: Serves as a versatile starting material for the scalable synthesis of complex heterocycles under Good Manufacturing Practice (GMP) conditions.
• Chemical Biology: Employed in the development of chemical probes and tool compounds for investigating biological pathways and target validation.
• Library Synthesis: A valuable scaffold for generating diverse compound libraries for high-throughput screening (HTS) campaigns.
• Academic Research: Used in universities and research institutes for methodological development in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	Ethyl 5-Boc-5-Aza-Spiro[3.4]Octane-2-Carboxylate
CAS No.	1251022-90-8
Molecular Formula	C15H25NO4
Molecular Weight	283.36 g/mol
Synonyms	Ethyl 5-[(tert-Butoxycarbonyl)amino]-5-azaspiro[3.4]octane-2-carboxylate; 5-Azaspiro[3.4]octane-2-carboxylic acid, 5-[(1,1-dimethylethoxy)carbonyl]-, ethyl ester; 5-Boc-5-aza-spiro[3.4]octane-2-carboxylic acid ethyl ester; Ethyl 5-(tert-butoxycarbonyl)-5-azaspiro[3.4]octane-2-carboxylate; 5-Aza-spiro[3.4]octane-2-carboxylic acid ethyl ester, N-Boc protected; Boc-5-Aza-Spiro[3.4]Octane-2-Carboxylic Acid Ethyl Ester; 1251022-90-8; tert-Butyl 2-(ethoxycarbonyl)-5-azaspiro[3.4]octane-5-carboxylate
EINECS	Contact for details

Quality Control

Our Ethyl 5-Boc-5-Aza-Spiro[3.4]Octane-2-Carboxylate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We adhere to ISO 9001 quality management standards, and custom synthesis can be performed under cGMP guidelines for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.