Description

8-Oxa-2-Aza-Spiro[4.5]Decane-2,4-Dicarboxylic Acid 2-tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its unique spirocyclic structure. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), offering a versatile building block for medicinal chemistry and drug discovery programs. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly in areas requiring sophisticated heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic molecules.
• Protease Inhibitor Synthesis: Serves as a precursor in the development of inhibitors targeting various protease enzymes.
• Chemical Biology Probes: Employed in the creation of specialized molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds under cGMP conditions.
• Academic Research: Used in university and institutional labs for exploratory synthetic chemistry and methodology development.

Basic Information

Product Name	8-Oxa-2-Aza-Spiro[4.5]Decane-2,4-Dicarboxylic Acid 2-tert-Butyl Ester
CAS No.	1251021-24-5
Molecular Formula	C14H23NO5
Molecular Weight	285.34 g/mol
Synonyms	2-(tert-Butyl) 4-ethyl 8-oxa-2-azaspiro[4.5]decane-2,4-dicarboxylate; 2-tert-Butyl 8-oxa-2-azaspiro[4.5]decane-2,4-dicarboxylate; 8-Oxa-2-azaspiro[4.5]decane-2,4-dicarboxylic acid, 2-(1,1-dimethylethyl) ester; Spirocyclic Oxazolidinone Ester; tert-Butyl 8-oxa-2-azaspiro[4.5]decane-2-carboxylate-4-carboxylate
EINECS	Contact for details

Quality Control

Our 8-Oxa-2-Aza-Spiro[4.5]Decane-2,4-Dicarboxylic Acid 2-tert-Butyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can support development projects requiring material produced under current Good Manufacturing Practice (cGMP) guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.