Description

5-Amino-2,3,5,6-tetrahydrospiro[indoline-3,4-pyran]-2-one (Wx105404) is a high-purity, advanced pharmaceutical intermediate characterized by its unique spirocyclic molecular architecture. This compound is of significant value for its role as a critical building block in the synthesis of novel, complex active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly within the fields of oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug candidates, especially those with spirocyclic or fused heterocyclic structures.
• Organic Synthesis Building Block: Utilized in medicinal chemistry for constructing complex molecular scaffolds due to its reactive amino and lactam functional groups.
• Research & Development (R&D): Serves as a standard or starting material in academic and industrial laboratories for studying structure-activity relationships (SAR) and novel synthetic pathways.
• API Manufacturing: Employed in the pilot-scale and commercial-scale synthesis of target active pharmaceutical ingredients requiring this specific spiro[indoline-3,4-pyran] core.

Basic Information

Product Name	5-Amino-2,3,5,6-tetrahydrospiro[indoline-3,4-pyran]-2-one (Wx105404)
CAS No.	1251021-08-5
Molecular Formula	C12H14N2O2
Molecular Weight	218.25 g/mol
Synonyms	WX-105404; Wx105404; 5-Amino-2,3,5,6-tetrahydrospiro[indole-3,4'-pyran]-2-one; 5-Amino-2,3,5,6-tetrahydrospiro[indoline-3,4-pyran]-2-one; Spiro[indoline-3,4-pyran]-2-one, 5-amino-2,3,5,6-tetrahydro-; 5-Amino-2,3,5,6-tetrahydrospiro[indoline-3,4'-pyran]-2-one
EINECS	Contact for details

Quality Control

Our 5-Amino-2,3,5,6-tetrahydrospiro[indoline-3,4-pyran]-2-one is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider inert atmosphere conditions to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.