Description

5-Benzyloxycarbonylamino-2-Aza-Spiro[3.3]Heptane-2-Carboxylic Acid tert-Butyl Ester is a sophisticated, high-purity pharmaceutical intermediate featuring a unique spirocyclic and protected amino acid structure. This compound is critical for medicinal chemistry research and development, serving as a key building block in the synthesis of novel drug candidates. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on developing new therapeutic agents, particularly in areas requiring constrained peptide mimetics and complex molecular architectures.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of active pharmaceutical ingredients (APIs) and novel drug candidates, especially those targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to introduce conformational constraint into peptide-based molecules.
• Protease Inhibitor Development: Serves as a core scaffold for designing inhibitors of specific enzymes, such as proteases, due to its spirocyclic structure mimicking transition states.
• Peptidomimetic Synthesis: Enables the creation of stable, bioavailable peptidomimetics by incorporating the 2-aza-spiro[3.3]heptane motif, which can improve metabolic stability and binding affinity.
• Chemical Biology Probes: Employed in the development of tool compounds and probes for studying biological pathways and protein function.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, advanced intermediates.

Basic Information

Product Name	5-Benzyloxycarbonylamino-2-Aza-Spiro[3.3]Heptane-2-Carboxylic Acid tert-Butyl Ester
CAS No.	1251021-00-7
Molecular Formula	C19H26N2O4
Molecular Weight	346.43 g/mol
Synonyms	5-[(Benzyloxycarbonyl)amino]-2-aza-spiro[3.3]heptane-2-carboxylic acid tert-butyl ester; 2-Aza-spiro[3.3]heptane-2-carboxylic acid, 5-[[(phenylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester; tert-Butyl 5-((benzyloxycarbonyl)amino)-2-azaspiro[3.3]heptane-2-carboxylate; Z-5-Amino-2-azaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester; Cbz-5-Amino-2-azaspiro[3.3]heptane-2-Boc; 2-Boc-5-Cbz-amino-2-azaspiro[3.3]heptane; (2-tert-Butoxycarbonyl-2-azaspiro[3.3]heptan-5-yl)carbamic acid benzyl ester
EINECS	Contact for details

Quality Control

Every batch of 5-Benzyloxycarbonylamino-2-Aza-Spiro[3.3]Heptane-2-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing all specifications are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.