Description

5-Oxo-2-Azaspiro[3.3]Heptane-2-Carboxylic Acid tert-Butyl Ester is a high-value, protected spirocyclic amino acid derivative serving as a critical synthetic intermediate. Its unique spiro[3.3]heptane scaffold and orthogonal protecting groups make it a versatile building block for constructing complex molecular architectures with precise stereochemistry. This compound is essential for medicinal chemistry research and process development in the pharmaceutical industry, particularly for the synthesis of novel drug candidates targeting central nervous system (CNS) disorders and other therapeutic areas.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs) and drug candidates.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical space.
• Peptidomimetics & Constrained Peptides: The spirocyclic structure is valuable for designing conformationally restricted peptide analogs to enhance metabolic stability and bioavailability.
• Chemical Biology Probes: Serves as a scaffold for developing tool compounds and probes to study biological targets and pathways.
• Process Chemistry Development: Employed in route scouting and scale-up synthesis for advanced pharmaceutical manufacturing.
• Library Synthesis: A valuable input for combinatorial and parallel synthesis to generate diverse compound libraries for high-throughput screening.

Basic Information

Product Name	5-Oxo-2-Azaspiro[3.3]Heptane-2-Carboxylic Acid tert-Butyl Ester
CAS No.	1251020-88-8
Molecular Formula	C11H17NO3
Molecular Weight	211.26 g/mol
Synonyms	tert-Butyl 5-oxo-2-azaspiro[3.3]heptane-2-carboxylate; 2-Azaspiro[3.3]heptane-2-carboxylic acid, 5-oxo-, 1,1-dimethylethyl ester; 2-(tert-Butoxycarbonyl)-2-azaspiro[3.3]heptan-5-one; Boc-2-azaspiro[3.3]heptan-5-one; 5-Oxo-2-azaspiro[3.3]heptane-2-carboxylic acid 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 5-Oxo-2-Azaspiro[3.3]Heptane-2-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, impurities, and physical characteristics are provided with every shipment. We support cGMP standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed under an inert atmosphere to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.