Description

6-Benzyl 2-tert-Butyl 10-Oxo-2,6,9-Triazaspiro[4.5]Decane-2,6-Dicarboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its complex spirocyclic and triaza scaffold. This compound is of significant value for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular architectures. It is primarily needed by research institutions, custom synthesis laboratories, and pharmaceutical companies engaged in the development of new drugs, especially those targeting central nervous system (CNS) disorders, oncology, and anti-infective agents.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the multi-step synthesis of complex drug candidates and novel chemical entities (NCEs).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic molecules.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for client-specific projects requiring spirocyclic frameworks.
• Protease Inhibitor Development: The triazaspiro[4.5]decane core is a privileged structure in the design of inhibitors for various enzymes, including proteases.
• Chemical Biology Probes: Utilized in the creation of molecular probes to study biological pathways and target validation.
• Scale-up and Process Chemistry: Supports the transition from milligram-scale discovery to gram/kilogram-scale production for clinical trial material.

Basic Information

Product Name	6-Benzyl 2-tert-Butyl 10-Oxo-2,6,9-Triazaspiro[4.5]Decane-2,6-Dicarboxylate
CAS No.	1251020-61-7
Molecular Formula	C21H29N3O5
Molecular Weight	403.48 g/mol
Synonyms	2,6,9-Triazaspiro[4.5]decane-2,6-dicarboxylic acid, 10-oxo-, 6-(phenylmethyl) ester, 2-(1,1-dimethylethyl) ester; 2-tert-Butyl 6-benzyl 10-oxo-2,6,9-triazaspiro[4.5]decane-2,6-dicarboxylate; tert-Butyl 6-(benzyloxycarbonyl)-10-oxo-2,6,9-triazaspiro[4.5]decane-2-carboxylate; 6-Benzyl 2-tert-butyl 10-oxo-2,6,9-triazaspiro[4.5]decane-2,6-dicarboxylate; Spirocyclic Triaza Intermediate; CAS 1251020-61-7.
EINECS	Contact for details

Quality Control

Our 6-Benzyl 2-tert-Butyl 10-Oxo-2,6,9-Triazaspiro[4.5]Decane-2,6-Dicarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic; therefore, containers should be kept tightly sealed in a dry environment. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.