Description

tert-Butyl 8-Oxa-2,5-Diazaspiro[3.5]Nonane-5-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic scaffold. This compound is a critical building block in modern medicinal chemistry, valued for its structural complexity and versatility in drug discovery. It is primarily utilized by research institutions and pharmaceutical companies for the synthesis of novel active pharmaceutical ingredients (APIs) targeting central nervous system (CNS) disorders and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those requiring spirocyclic or bridged heterocyclic architectures.
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• CNS Drug Development: Used in the research and development of therapeutics for neurological conditions, leveraging its potential for blood-brain barrier penetration.
• Proteolysis Targeting Chimera (PROTAC) Linkers: Its rigid, three-dimensional structure makes it a candidate for use in the linker region of bifunctional PROTAC molecules.
• Chemical Biology Probes: Employed in the design of selective molecular probes to study enzyme function and biological pathways.
• Process Chemistry & Scale-Up: Supplied for route scouting, optimization, and pilot-scale manufacturing of clinical trial materials.

Basic Information

Product Name	tert-Butyl 8-Oxa-2,5-Diazaspiro[3.5]Nonane-5-Carboxylate
CAS No.	1251020-41-3
Molecular Formula	C11H20N2O3
Molecular Weight	228.29 g/mol
Synonyms	5-Boc-8-oxa-2,5-diazaspiro[3.5]nonane; tert-Butyl 8-oxa-2,5-diazaspiro[3.5]nonane-5-carboxylate; 8-Oxa-2,5-diazaspiro[3.5]nonane-5-carboxylic acid, 1,1-dimethylethyl ester; 2,5-Diazaspiro[3.5]nonane-5-carboxylic acid, 8-oxa-, 1,1-dimethylethyl ester; Boc-8-oxa-2,5-diazaspiro[3.5]nonane; 5-(tert-Butoxycarbonyl)-8-oxa-2,5-diazaspiro[3.5]nonane; Spirocyclic Boc-protected diamine ether
EINECS	Contact for details

Quality Control

Every batch of tert-Butyl 8-Oxa-2,5-Diazaspiro[3.5]Nonane-5-Carboxylate is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.