Description

Racemic-(1S,4S,5S)-1'-(tert-Butoxycarbonyl)Spiro[Bicyclo[2.2.1]Hept[2]Ene-7,4'-Piperidine]-5-Carboxylic Acid is a sophisticated, high-purity chiral building block featuring a complex spirocyclic and norbornene-derived scaffold. This compound is critical for medicinal chemistry research and development, serving as a key intermediate in the synthesis of novel active pharmaceutical ingredients (APIs) and complex organic molecules. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers focused on developing new therapeutics, particularly in areas requiring rigid, three-dimensional molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, especially those targeting the central nervous system (CNS) and other therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to introduce conformational constraint and explore novel chemical space.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential component for constructing linkers or warheads due to its rigid, functionalized structure.
• Asymmetric Synthesis: Employed as a starting material or intermediate in complex multi-step asymmetric syntheses to construct stereochemically defined molecules.
• Chemical Biology Probes: Useful for creating molecular probes to study biological pathways and protein function.
• Academic Research: Utilized in university and institutional labs for advanced organic synthesis methodology development and novel compound library generation.

Basic Information

Product Name	Racemic-(1S,4S,5S)-1'-(tert-Butoxycarbonyl)Spiro[Bicyclo[2.2.1]Hept[2]Ene-7,4'-Piperidine]-5-Carboxylic Acid
CAS No.	1251015-75-4
Molecular Formula	C18H25NO4
Molecular Weight	319.40 g/mol
Synonyms	(±)-(1S,4S,5S)-1'-Boc-spiro[bicyclo[2.2.1]hept[2]ene-7,4'-piperidine]-5-carboxylic acid; 1'-[(1,1-Dimethylethoxy)carbonyl]spiro[bicyclo[2.2.1]hept[2]ene-7,4'-piperidine]-5-carboxylic acid; 1'-Boc-5-carboxyspiro[bicyclo[2.2.1]hept[2]ene-7,4'-piperidine]; tert-Butyl 5-carboxyspiro[bicyclo[2.2.1]hept-2-ene-7,4'-piperidine]-1'-carboxylate; Bicyclo[2.2.1]hept-2-ene-7-spiro-4'-piperidine-5-carboxylic acid, 1'-(tert-butoxycarbonyl)-; CAS 1251015-75-4.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality management systems. Every batch is subjected to comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR (1H, 13C) for structural confirmation, and mass spectrometry. We provide detailed Certificates of Analysis (COA) with each shipment, ensuring full traceability and compliance with the specifications agreed upon with our clients. Our facilities operate under cGMP principles suitable for the production of non-GMP pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent degradation. Keep the container tightly sealed in a desiccated environment when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	Racemic mixture (1:1 ratio)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.