Description

5-Oxa-2-Aza-Spiro[3.4]Octane-2,6-Dicarboxylic Acid 2-tert-Butyl Ester is a high-value, multifunctional spirocyclic building block used in advanced organic synthesis. This compound is critical for medicinal chemistry research and development, particularly in the construction of novel, three-dimensional molecular scaffolds. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers seeking to develop new active pharmaceutical ingredients (APIs) and bioactive molecules.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing novel spirocyclic drug candidates targeting CNS disorders, oncology, and infectious diseases.
• Medicinal Chemistry Research: Used in fragment-based drug discovery and combinatorial chemistry libraries to explore new chemical space and improve pharmacokinetic properties.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a versatile linker or core component in the design of bifunctional molecules for targeted protein degradation.
• Agrochemical Synthesis: Employed in the research and development of new-generation herbicides and fungicides with spirocyclic motifs.
• Material Science Precursor: Potential use in synthesizing specialty polymers and ligands for catalysis with unique steric and electronic properties.

Basic Information

Product Name	5-Oxa-2-Aza-Spiro[3.4]Octane-2,6-Dicarboxylic Acid 2-tert-Butyl Ester
CAS No.	1251006-00-4
Molecular Formula	C12H19NO5
Molecular Weight	257.28 g/mol
Synonyms	2-(tert-Butyl) 6-Hydrogen 5-Oxa-2-Aza-Spiro[3.4]Octane-2,6-Dicarboxylate; 2-Aza-5-oxaspiro[3.4]octane-2,6-dicarboxylic acid, 2-(1,1-dimethylethyl) ester; 2-tert-Butyl 5-oxa-2-azaspiro[3.4]octane-2,6-dicarboxylate; 2-N-Boc-6-carboxy-5-oxa-2-azaspiro[3.4]octane; Spirocyclic Proline Derivative; tert-Butyl 2,6-dioxo-5-oxa-2-azaspiro[3.4]octane-2-carboxylate
EINECS	Contact for details

Quality Control

Our 5-Oxa-2-Aza-Spiro[3.4]Octane-2,6-Dicarboxylic Acid 2-tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent chemical identity. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to prevent moisture absorption and contamination. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.