Description

tert-Butyl 5-Oxa-2,8-Diazaspiro[3.5]Nonane-8-Carboxylate is a high-purity, advanced pharmaceutical intermediate belonging to the spirocyclic amine family. This compound is a critical building block in modern medicinal chemistry, valued for its unique rigid scaffold which is instrumental in modulating the physicochemical and pharmacokinetic properties of drug candidates. It is primarily utilized by research and development teams in the pharmaceutical and biotechnology sectors for the synthesis of novel therapeutic agents, particularly in central nervous system (CNS) and oncology research pipelines.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of new active pharmaceutical ingredients (APIs), especially those targeting complex biological pathways.
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing compound libraries in drug discovery programs, enabling structure-activity relationship (SAR) studies.
• CNS Drug Development: Employed in the synthesis of potential therapeutics for neurological disorders due to the favorable properties imparted by its spirocyclic structure for blood-brain barrier penetration.
• Oncological Agent Synthesis: Serves as a building block for novel small molecule inhibitors and targeted cancer therapies.
• Chemical Biology Probes: Utilized in the creation of specialized molecular probes for studying enzyme function and protein-protein interactions.
• Process Chemistry & Scale-Up: Supplied for route scouting and optimization during the transition from laboratory-scale synthesis to commercial manufacturing.

Basic Information

Product Name	tert-Butyl 5-Oxa-2,8-Diazaspiro[3.5]Nonane-8-Carboxylate
CAS No.	1251005-61-4
Molecular Formula	C11H20N2O3
Molecular Weight	228.29 g/mol
Synonyms	8-Boc-2,8-diazaspiro[3.5]nonan-5-one; tert-Butyl 2,8-diazaspiro[3.5]nonane-8-carboxylate, 5-oxa-; 5-Oxa-2,8-diazaspiro[3.5]nonane-8-carboxylic acid, 1,1-dimethylethyl ester; 2,8-Diazaspiro[3.5]nonan-5-one, 8-(tert-butoxycarbonyl)-; Boc-5-oxa-2,8-diazaspiro[3.5]nonane; 8-N-Boc-5-oxa-2,8-diazaspiro[3.5]nonane
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-Oxa-2,8-Diazaspiro[3.5]Nonane-8-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring the material meets the stringent requirements for pharmaceutical R&D and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); containers must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.