Description

6-Carboxymethyl-2-Aza-Spiro[3.3]Heptane-2-Carboxylicacidtert-Butylester is a high-value, multifunctional spirocyclic building block designed for advanced organic synthesis. Its unique constrained spiro[3.3]heptane scaffold and dual carboxylic acid protection make it a critical intermediate for constructing complex molecular architectures with enhanced three-dimensional properties. This compound is primarily sought after by pharmaceutical and agrochemical R&D teams for applications in medicinal chemistry, including the development of novel protease inhibitors and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel drug candidates, particularly for targeting proteases and other enzymes.
• Medicinal Chemistry: Used to introduce the rigid, three-dimensional spiro[3.3]heptane core into lead compounds to improve metabolic stability, potency, and selectivity.
• Agrochemical Research: Serves as a precursor in the development of new generation pesticides and herbicides with novel modes of action.
• Chemical Biology: Employed in the design and synthesis of molecular probes and tool compounds for studying biological pathways.
• Peptidomimetics: Facilitates the creation of conformationally restricted peptide analogs to enhance bioavailability and receptor binding affinity.
• Material Science: Potential monomer or cross-linker for creating specialty polymers with unique thermal and mechanical properties.

Basic Information

Product Name	6-Carboxymethyl-2-Aza-Spiro[3.3]Heptane-2-Carboxylicacidtert-Butylester
CAS No.	1251002-39-7
Molecular Formula	C13H21NO4
Molecular Weight	255.31 g/mol
Synonyms	2-(tert-Butoxycarbonyl)-2-aza-6-spiro[3.3]heptaneacetic acid; 2-Aza-6-spiro[3.3]heptane-2-carboxylic acid, 6-(carboxymethyl)-, 1,1-dimethylethyl ester; tert-Butyl 6-(carboxymethyl)-2-azaspiro[3.3]heptane-2-carboxylate; 6-(Carboxymethyl)-2-azaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester; Boc-6-Carboxymethyl-2-Aza-Spiro[3.3]Heptane; 2-Boc-2,6-Diazaspiro[3.3]heptane-6-acetic acid (common misnomer); Aza-spiro[3.3]heptane Boc-protected acetic acid derivative.
EINECS	Contact for details

Quality Control

Our production of 6-Carboxymethyl-2-Aza-Spiro[3.3]Heptane-2-Carboxylicacidtert-Butylester adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. We employ advanced analytical techniques including HPLC, GC, NMR, and MS for comprehensive characterization and purity verification. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming specifications for identity, assay, and impurity profiles. Our quality system is designed to support cGMP and ISO standards for pharmaceutical intermediate manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.