Description

7-Aminomethyl-6-Oxa-2-Aza-Spiro[3.4]Octane-2-Carboxylic Acid tert-Butyl Ester is a sophisticated spirocyclic building block of significant interest in modern pharmaceutical research and development. Its unique constrained bicyclic structure, featuring both oxa- and aza-heterocycles, makes it a valuable scaffold for designing novel bioactive molecules with improved metabolic stability and target selectivity. This high-purity intermediate is primarily utilized by medicinal chemists and process development scientists in the synthesis of innovative drug candidates, particularly in therapeutic areas requiring complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel Active Pharmaceutical Ingredients (APIs) targeting central nervous system (CNS) disorders, infectious diseases, and oncology.
• Medicinal Chemistry Scaffold: Used in hit-to-lead and lead optimization campaigns to introduce conformational restraint, potentially improving potency, selectivity, and pharmacokinetic properties of drug candidates.
• Protease Inhibitor Development: The spirocyclic β-amino acid ester motif is valuable for constructing inhibitors of various proteases, a crucial class of therapeutic targets.
• Peptidomimetics Research: Serves as a constrained, non-natural amino acid analog for creating stable peptide mimics with enhanced bioavailability and resistance to enzymatic degradation.
• Chemical Biology Probes: Employed in the synthesis of specialized molecular probes to study enzyme function and biological pathways.
• Process Chemistry & Scale-Up: Supplied for route scouting, optimization, and cGMP manufacturing of clinical trial materials under controlled conditions.

Basic Information

Product Name	7-Aminomethyl-6-Oxa-2-Aza-Spiro[3.4]Octane-2-Carboxylic Acid tert-Butyl Ester
CAS No.	1251002-26-2
Molecular Formula	C12H22N2O3
Molecular Weight	242.32 g/mol
Synonyms	tert-Butyl 7-(aminomethyl)-6-oxa-2-azaspiro[3.4]octane-2-carboxylate; 2-Azaspiro[3.4]octane-2-carboxylic acid, 7-(aminomethyl)-6-oxa-, 1,1-dimethylethyl ester; 6-Oxa-2-azaspiro[3.4]octane-2-carboxylic acid, 7-(aminomethyl)-, tert-butyl ester; (7-Aminomethyl-6-oxa-2-aza-spiro[3.4]oct-2-yl)-carboxylic acid tert-butyl ester; Spirocyclic β-amino acid tert-butyl ester; Boc-protected spirocyclic amino acid derivative.
EINECS	Contact for details

Quality Control

Our 7-Aminomethyl-6-Oxa-2-Aza-Spiro[3.4]Octane-2-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and NMR for structural confirmation, to ensure it meets the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles. We support development with custom synthesis and specification tailoring to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture uptake. Recommended long-term storage temperature is 2-8°C for optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.