Description

2-Methyl-2-((2'-Oxospiro[Azetidine-3,3'-Indole]-1-Yl)Carbonyloxy)Propylidyne is a high-purity, advanced pharmaceutical intermediate characterized by its complex spirocyclic indole-azetidine structure. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel therapeutic agents with targeted biological activity. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new drugs, particularly in the areas of oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel small-molecule drug candidates, especially those targeting specific enzyme pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes within R&D laboratories.
• Protease Inhibitor Development: The spirocyclic core structure is valuable for creating potential inhibitors for various protease targets.
• Chemical Biology Probes: Serves as a scaffold for developing tool compounds to study biological mechanisms and disease pathways.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for bespoke synthesis projects under cGMP conditions.

Basic Information

Product Name	2-Methyl-2-((2'-Oxospiro[Azetidine-3,3'-Indole]-1-Yl)Carbonyloxy)Propylidyne
CAS No.	1251001-73-6
Molecular Formula	C16H16N2O3
Molecular Weight	284.31 g/mol
Synonyms	1-[(2-Methyl-2-oxido-1-oxoprop-2-en-1-yl)oxy]carbonyl]spiro[azetidine-3,3'-indol]-2'(1'H)-one; 2-Methyl-2-((2'-oxospiro[azetidine-3,3'-indole]-1-yl)carbonyloxy)propylidyne; Spiro[azetidine-3,3'-indole]-2'-one derivative; CAS 1251001-73-6; Advanced Spirocyclic Intermediate; 1-Carboxyvinyl 2'-oxospiro(azetidine-3,3'-indole)-1-carboxylate (tautomer).
EINECS	Contact for details

Quality Control

Our 2-Methyl-2-((2'-Oxospiro[Azetidine-3,3'-Indole]-1-Yl)Carbonyloxy)Propylidyne is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure compliance with research and development standards. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.