Description

4-Hydroxymethyl-3-Isopropyl-3,4,6,7-Tetrahydro-Imidazo[4,5-C]Pyridine-5-Carboxylic Acid tert-Butyl Ester is a sophisticated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel pharmaceutical agents, particularly those targeting complex biological pathways. It is primarily needed by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the synthesis of high-value active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and the exploration of new chemical entities (NCEs).
• Process Chemistry & Scale-Up: Used in route scouting and optimization for the efficient, large-scale production of target molecules under Good Manufacturing Practice (GMP) guidelines.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity advanced intermediates.
• Academic Research: Employed in university and institutional labs for methodological development and the study of novel heterocyclic reactions.
• Proteolysis Targeting Chimera (PROTAC) Development: Potential use as a component in the linker or ligand design for bifunctional degrader molecules.

Basic Information

Product Name	4-Hydroxymethyl-3-Isopropyl-3,4,6,7-Tetrahydro-Imidazo[4,5-C]Pyridine-5-Carboxylic Acid tert-Butyl Ester
CAS No.	1251001-42-9
Molecular Formula	C16H25N3O3
Molecular Weight	307.39 g/mol
Synonyms	tert-Butyl 4-(hydroxymethyl)-3-(propan-2-yl)-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridine-5-carboxylate; 3-Isopropyl-4-hydroxymethyl-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridine-5-carboxylic acid tert-butyl ester; 5H-Imidazo[4,5-c]pyridine-5-carboxylic acid, 3,4,6,7-tetrahydro-4-(hydroxymethyl)-3-(1-methylethyl)-, 1,1-dimethylethyl ester; 4-(Hydroxymethyl)-3-isopropyl-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridine-5-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for critical research and development work. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, identity, and impurity profiles. We support development projects with custom synthesis and can tailor specifications to meet specific project requirements, including those for pre-clinical and clinical-stage materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture uptake, which can affect stability and handling properties. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.