Description

5-Oxo-8-Phenyl-2,6-Diaza-Spiro[3.4]Octane-2-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate belonging to the spirocyclic diaza compound class. Its unique spiro[3.4]octane scaffold makes it a critical building block for medicinal chemistry research and the synthesis of novel active pharmaceutical ingredients (APIs). This compound is essential for R&D and production teams in the pharmaceutical and biotechnology sectors focused on developing new therapeutic agents, particularly in central nervous system (CNS) and metabolic disease areas.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates and novel bioactive molecules.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Protease Inhibitor Development: The diaza-spiro structure is valuable for creating inhibitors targeting specific enzymes.
• Chemical Biology Probes: Serves as a core structure for developing tool compounds to study biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom API synthesis projects.
• Academic Research: Utilized in university and institutional labs for advanced organic synthesis methodology and heterocyclic chemistry studies.

Basic Information

Product Name	5-Oxo-8-Phenyl-2,6-Diaza-Spiro[3.4]Octane-2-Carboxylic Acid tert-Butyl Ester
CAS No.	1251000-17-5
Molecular Formula	C₁₇H₂₂N₂O₃
Molecular Weight	302.37 g/mol
Synonyms	tert-Butyl 5-oxo-8-phenyl-2,6-diazaspiro[3.4]octane-2-carboxylate; 2,6-Diaza-spiro[3.4]octane-2-carboxylic acid, 5-oxo-8-phenyl-, 1,1-dimethylethyl ester; 8-Phenyl-5-oxo-2,6-diazaspiro[3.4]octane-2-carboxylic acid tert-butyl ester; 2-N-Boc-8-phenyl-2,6-diazaspiro[3.4]octan-5-one; Spirocyclic Diaza Compound 1251000-17-5
EINECS	Contact for details

Quality Control

Our 5-Oxo-8-Phenyl-2,6-Diaza-Spiro[3.4]Octane-2-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding pharmaceutical R&D. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality systems are designed to support cGMP compliance for advanced intermediate production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.