Description

7-[(tert-Butoxy)Carbonyl]-7-Azaspiro[3.5]Nonane-1-Carboxylic Acid is a high-value, advanced pharmaceutical intermediate featuring a unique spirocyclic and protected amine structure. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for constructing complex molecular architectures. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on developing novel active pharmaceutical ingredients (APIs), particularly in the areas of central nervous system (CNS) and metabolic disease therapeutics.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of novel drug candidates, especially those requiring spirocyclic scaffolds.
• Proteolysis Targeting Chimera (PROTAC) Development: Used as a linker or component in the design of bifunctional molecules for targeted protein degradation.
• Peptidomimetics & Constrained Peptide Synthesis: The spiro[3.5]nonane core provides rigid, three-dimensional structure to mimic peptide secondary structures.
• Chemical Biology Probe Synthesis: Employed in creating tool compounds for studying enzyme function and biological pathways.
• Building Block for Kinase Inhibitors: The carboxylic acid and protected amine functionalities allow for diverse derivatization common in kinase inhibitor libraries.
• Material Science Research: Potential monomer or precursor for specialty polymers with unique thermal and mechanical properties.

Basic Information

Item	Details
Product Name	7-[(tert-Butoxy)Carbonyl]-7-Azaspiro[3.5]Nonane-1-Carboxylic Acid
CAS No.	1250999-64-4
Molecular Formula	C14H23NO4
Molecular Weight	269.34 g/mol
Synonyms	1-Carboxy-7-azaspiro[3.5]nonane-7-carboxylic acid tert-butyl ester; 7-(tert-Butoxycarbonyl)-7-azaspiro[3.5]nonane-1-carboxylic acid; 7-Boc-7-azaspiro[3.5]nonane-1-carboxylic acid; 7-Azaspiro[3.5]nonane-1-carboxylic acid, 7-[(1,1-dimethylethoxy)carbonyl]-; Boc-7-azaspiro[3.5]nonane-1-COOH; tert-Butyl 1-carboxy-7-azaspiro[3.5]nonane-7-carboxylate; 7-Azaspiro[3.5]nonane-1-carboxylic acid, N-Boc-protected; 7-N-Boc-7-azaspiro[3.5]nonane-1-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of 7-[(tert-Butoxy)Carbonyl]-7-Azaspiro[3.5]Nonane-1-Carboxylic Acid adheres to stringent quality management systems, ensuring batch-to-batch consistency for critical R&D and cGMP starting material applications. All materials are characterized by advanced analytical techniques including HPLC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your regulatory and research documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.