Description

n-Boc-3-(Iodomethyl)-2-Oxa-8-Azaspiro[4.5]Decane is a versatile and high-value protected spirocyclic building block used in advanced organic synthesis. Its core value lies in providing a rigid, functionalized scaffold that is critical for constructing complex nitrogen-containing heterocycles, particularly in pharmaceutical research. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-purity intermediates for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Scaffold: Used to build diverse compound libraries for high-throughput screening (HTS) and structure-activity relationship (SAR) studies due to its spirocyclic and protected amine functionality.
• Peptidomimetic Synthesis: Serves as a constrained, non-peptide backbone mimic for developing protease inhibitors and other bioactive peptides.
• Alkaloid Synthesis: Employed in the total synthesis of complex natural products and alkaloids that contain bridged or fused nitrogen heterocycles.
• Ligand and Catalyst Development: Acts as a starting material for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Probes: Utilized to develop tool compounds and molecular probes for investigating biological pathways and target validation.

Basic Information

Product Name	n-Boc-3-(Iodomethyl)-2-Oxa-8-Azaspiro[4.5]Decane
CAS No.	1250998-93-6
Molecular Formula	C13H22INO3
Molecular Weight	367.22 g/mol
Synonyms	1,1-Dimethylethyl 3-(iodomethyl)-2-oxa-8-azaspiro[4.5]decane-8-carboxylate; tert-Butyl 3-(iodomethyl)-2-oxa-8-azaspiro[4.5]decane-8-carboxylate; Boc-3-(iodomethyl)-2-oxa-8-azaspiro[4.5]decane; 8-Boc-3-(iodomethyl)-2-oxa-8-azaspiro[4.5]decane; 3-(Iodomethyl)-2-oxa-8-azaspiro[4.5]decane-8-carboxylic acid tert-butyl ester; (3-(Iodomethyl)-2-oxa-8-azaspiro[4.5]decan-8-yl)(tert-butoxy)methanone
EINECS	Contact for details

Quality Control

Our n-Boc-3-(Iodomethyl)-2-Oxa-8-Azaspiro[4.5]Decane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed under an inert atmosphere to minimize degradation and ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.