Description

7-Amino-5-Oxa-2-Azaspiro[3.4]Octane-2-Carboxylic Acid 1,1-Dimethylethyl Ester is a high-value, protected amino acid derivative featuring a unique spirocyclic scaffold, making it a critical building block for advanced organic synthesis. Its primary value lies in serving as a key chiral intermediate for constructing complex molecules in pharmaceutical research and development. This compound is essential for medicinal chemists and process R&D teams working on novel active pharmaceutical ingredients (APIs), particularly in the areas of central nervous system (CNS) drugs and protease inhibitors.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of novel drug candidates, especially in neurological and antiviral therapeutic areas.
• Peptidomimetics Construction: Used to incorporate constrained, spirocyclic motifs into peptide backbones to enhance metabolic stability and receptor selectivity.
• Protease Inhibitor Development: Serves as a core scaffold or side-chain component in the design of inhibitors for various protease enzymes.
• Chemical Biology Probes: Employed in the creation of specialized molecular probes for studying enzyme function and protein-protein interactions.
• Asymmetric Synthesis: Utilized as a starting material or intermediate in catalytic asymmetric reactions to introduce stereogenic centers.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP guidelines.

Basic Information

Product Name	7-Amino-5-Oxa-2-Azaspiro[3.4]Octane-2-Carboxylic Acid 1,1-Dimethylethyl Ester
CAS No.	1250998-24-3
Molecular Formula	C11H20N2O3
Molecular Weight	228.29 g/mol
Synonyms	tert-Butyl 7-amino-5-oxa-2-azaspiro[3.4]octane-2-carboxylate; 2-Azaspiro[3.4]octane-2-carboxylic acid, 7-amino-5-oxa-, 1,1-dimethylethyl ester; Boc-Protected 7-Amino-5-oxa-2-azaspiro[3.4]octane; (S)-tert-Butyl 7-amino-5-oxa-2-azaspiro[3.4]octane-2-carboxylate (if enantiomerically pure); Amino-Oxa-Azaspirooctane Boc Ester; Spirocyclic β-Amino Acid Boc Ester
EINECS	Contact for details

Quality Control

Our production of 7-Amino-5-Oxa-2-Azaspiro[3.4]Octane-2-Carboxylic Acid 1,1-Dimethylethyl Ester adheres to stringent quality protocols suitable for research and pharmaceutical development. Each batch undergoes comprehensive analytical testing, including chiral purity assessment, to ensure high chemical and isomeric purity. Certificates of Analysis (COA) detailing identity, purity (by HPLC), and impurity profiles are provided with every shipment. We support development projects with custom synthesis capabilities under controlled conditions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). For long-term storage, consider storing under an inert atmosphere (e.g., nitrogen or argon) to maintain stability. Keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee (if applicable)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.