Description

Racemic-(1S,3S,4R)-2-Benzyl 1'-tert-Butyl 3-Ethyl 2-Azaspiro[Bicyclo[2.2.1]Heptane-7,4'-Piperidine]-1',2,3-Tricarboxylate is a complex, multi-functional chiral spirocyclic building block of significant interest in advanced organic synthesis. Its intricate molecular architecture, featuring a fused norbornane and piperidine system with multiple protected carboxylate groups, makes it a versatile intermediate for constructing sophisticated three-dimensional pharmacophores. This compound is primarily utilized by pharmaceutical R&D organizations and fine chemical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral targets.

Application

• Key chiral intermediate in the synthesis of complex drug candidates and bioactive molecules.
• Building block for spirocyclic compound libraries used in high-throughput screening and medicinal chemistry programs.
• Precursor for the development of protease inhibitors and other enzyme-targeted therapeutics.
• Research chemical for studying structure-activity relationships (SAR) in drug discovery.
• Intermediate in the preparation of ligands for asymmetric catalysis.
• Starting material for the synthesis of natural product analogs with complex polycyclic frameworks.

Basic Information

Product Name	Racemic-(1S,3S,4R)-2-Benzyl 1'-tert-Butyl 3-Ethyl 2-Azaspiro[Bicyclo[2.2.1]Heptane-7,4'-Piperidine]-1',2,3-Tricarboxylate
CAS No.	1250997-96-6
Molecular Formula	C29H39N1O6
Molecular Weight	497.63 g/mol
Synonyms	2-Azaspiro[bicyclo[2.2.1]heptane-7,4'-piperidine]-1',2,3-tricarboxylic acid, 1'-(1,1-dimethylethyl) 2-(phenylmethyl) 3-ethyl ester, (1S,3S,4R)-rel-; 1'-tert-Butyl 2-benzyl 3-ethyl 2-azaspiro[bicyclo[2.2.1]heptane-7,4'-piperidine]-1',2,3-tricarboxylate; rac-(1S,3S,4R)-2-Benzyl 1'-tert-butyl 3-ethyl 2-azaspiro[bicyclo[2.2.1]heptane-7,4'-piperidine]-1',2,3-tricarboxylate; Spirocyclic Norbornane-Piperidine Tricarboxylate Ester; CAS 1250997-96-6.
EINECS	Contact for details

Quality Control

Our production of this advanced pharmaceutical intermediate adheres to strict quality management systems. Every batch is characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity (where applicable), and impurity profiles is provided with each shipment. We support development and commercial projects requiring compliance with ICH guidelines and can tailor specifications to meet specific project needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for prolonged operations to ensure stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.