Description

tert-Butyl 2-oxo-8-azaspiro[4.5]decane-8-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic and lactam structure. This compound is a critical building block in modern medicinal chemistry, valued for its role in constructing complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and other therapeutic agents.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the multi-step synthesis of complex drug candidates and novel bioactive molecules.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities, especially those targeting neurological pathways.
• API Development: Serves as a core scaffold or a protected intermediate in the production route of potential Active Pharmaceutical Ingredients (APIs).
• Spirocyclic Compound Synthesis: Essential for introducing the constrained, three-dimensional spiro[4.5]decane framework into target molecules to modulate their physicochemical and pharmacological properties.
• Process Chemistry & Scale-up: Supplied for route scouting, process development, and cGMP manufacturing of clinical trial materials.
• Contract Research & Manufacturing (CRO/CMO): A critical raw material for organizations providing custom synthesis and development services to the biopharma industry.

Basic Information

Product Name	tert-Butyl 2-oxo-8-azaspiro[4.5]decane-8-carboxylate
CAS No.	1250994-14-9
Molecular Formula	C14H23NO3
Molecular Weight	253.34 g/mol
Synonyms	8-Boc-2-oxo-8-azaspiro[4.5]decane; tert-Butyl 2-oxo-8-azaspiro[4.5]decane-8-carboxylate; 2-Oxo-8-azaspiro[4.5]decane-8-carboxylic acid tert-butyl ester; 8-(tert-Butoxycarbonyl)-8-azaspiro[4.5]decan-2-one; Boc-8-azaspiro[4.5]decan-2-one; 8-Azaspiro[4.5]decan-2-one, 8-(1,1-dimethylethoxy)carbonyl]-; 8-Boc-8-azaspiro[4.5]decan-2-one
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-oxo-8-azaspiro[4.5]decane-8-carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with detailed specifications for all critical parameters. Our quality commitment supports applications from early-stage research through to pre-clinical and clinical development, with the capability to meet custom purity requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.