Description

tert-Butyl 2,3-Dihydro-1H-Spiro[Benzo[E][1,4]Oxazepine-5,4'-Piperidine]-1'-Carboxylate is a high-purity, advanced pharmaceutical intermediate of significant importance in modern drug discovery. This compound, with CAS number 1250991-79-7, serves as a critical building block for the synthesis of novel therapeutic agents, particularly in central nervous system (CNS) and psychiatric disorder research. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing innovative small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates targeting neurological and psychiatric conditions.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for compounds interacting with specific CNS receptors.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential component in the linker or ligand design for targeted protein degradation platforms.
• Chemical Biology Probes: Utilized in the development of tool compounds for studying biological pathways and target validation.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for client-specific projects requiring complex spirocyclic architectures.
• Academic Research: Used in university and institutional labs for exploratory organic synthesis and pharmacological studies.

Basic Information

Product Name	tert-Butyl 2,3-Dihydro-1H-Spiro[Benzo[E][1,4]Oxazepine-5,4'-Piperidine]-1'-Carboxylate
CAS No.	1250991-79-7
Molecular Formula	C19H26N2O3
Molecular Weight	330.43 g/mol
Synonyms	1'-Boc-2,3-dihydro-1H-spiro[benzo[e][1,4]oxazepine-5,4'-piperidine]; tert-Butyl 2,3-dihydrospiro[1,4-benzoxazepine-5,4'-piperidine]-1'-carboxylate; 1,4-Benzoxazepine, 2,3-dihydro-5-spiro-4'-piperidinyl-, 1'-carboxylic acid, 1,1-dimethylethyl ester; 1,1-Dimethylethyl 2,3-dihydro-5-spiro-4'-piperidinyl-1,4-benzoxazepine-1'-carboxylate; BOC-Spiro(Benzoxazepine-Piperidine); 1250991-79-7; Spiro[benzo[e][1,4]oxazepine-5,4'-piperidine]-1'-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 2,3-Dihydro-1H-Spiro[Benzo[E][1,4]Oxazepine-5,4'-Piperidine]-1'-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.