Description

2-(Allyloxycarbonyl)-8-(tert-Butoxycarbonyl)-2,8-Diazaspiro[4.5]Decane-3-Carboxylic Acid is a sophisticated, multi-functional spirocyclic building block designed for advanced organic synthesis. This compound matters because it provides a protected, reactive scaffold essential for constructing complex nitrogen-containing heterocycles, a core structural motif in modern pharmaceuticals. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the research and development of new therapeutic agents, particularly in areas like central nervous system (CNS) disorders and oncology.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs) targeting spirocyclic pharmacophores.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) around constrained diazaspiro structures.
• Peptidomimetic Development: Serves as a rigid, non-natural amino acid analog for creating conformationally restricted peptides with enhanced metabolic stability.
• Chemical Biology Probe Synthesis: Employed to build molecular tools for studying enzyme function and protein-protein interactions.
• Library Synthesis for High-Throughput Screening: A valuable building block for generating diverse compound libraries focused on spirocyclic chemical space.
• Process Chemistry & Scale-Up: Used in route development and kilogram-scale production of candidate drugs during clinical trials.

Basic Information

Product Name	2-(Allyloxycarbonyl)-8-(tert-Butoxycarbonyl)-2,8-Diazaspiro[4.5]Decane-3-Carboxylic Acid
CAS No.	1250991-77-5
Molecular Formula	C18H28N2O6
Molecular Weight	368.43 g/mol
Synonyms	2,8-Diazaspiro[4.5]decane-3-carboxylic acid, 2-[(2-propen-1-yloxy)carbonyl]-8-[(1,1-dimethylethoxy)carbonyl]-; 2-(Allyloxycarbonyl)-8-Boc-2,8-diazaspiro[4.5]decane-3-carboxylic acid; 2-Alloc-8-Boc-2,8-diazaspiro[4.5]decane-3-carboxylic acid; Boc-Alloc-Diazaspirodecane Carboxylic Acid; 3-Carboxy-2,8-diazaspiro[4.5]decane-2,8-dicarboxylic acid 2-allyl 8-tert-butyl ester; 2-(Allyloxycarbonyl)-8-(tert-butoxycarbonyl)-2,8-diazaspiro[4.5]decane-3-carboxylic acid; 2,8-Diazaspiro[4.5]decane-2,8,3-tricarboxylic acid, 2-allyl 8-tert-butyl 3-hydrogen ester.
EINECS	Contact for details

Quality Control

Our production of 2-(Allyloxycarbonyl)-8-(tert-Butoxycarbonyl)-2,8-Diazaspiro[4.5]Decane-3-Carboxylic Acid adheres to stringent quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our commitment to quality supports compliance with cGMP guidelines for advanced pharmaceutical intermediates, ensuring reliability for your most critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. The compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from strong acids/bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.