Description

3-(2,2,2-Trifluoroethoxy)Pyridine-2-Carboxylic Acid is a high-value fluorinated pyridine derivative, serving as a critical advanced pharmaceutical intermediate (API intermediate) and a versatile building block in modern synthetic chemistry. Its unique structure, featuring a trifluoroethoxy side chain, is engineered to impart enhanced metabolic stability and bioavailability to target molecules. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and material science sectors seeking to incorporate fluorine chemistry for novel product development.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) drugs and kinase inhibitors.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides and fungicides, where the trifluoroethoxy group can enhance biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Precursor: Employed in the synthesis of functionalized polymers and liquid crystals with tailored electronic or optical properties.
• Chemical Biology Probe Development: Utilized as a building block for creating fluorescent tags or molecular probes for biochemical assays.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis projects requiring fluorinated heterocyclic architectures.

Basic Information

Product Name	3-(2,2,2-Trifluoroethoxy)Pyridine-2-Carboxylic Acid
CAS No.	1250130-41-6
Molecular Formula	C8H6F3NO3
Molecular Weight	221.13 g/mol
Synonyms	2-Pyridinecarboxylic acid, 3-(2,2,2-trifluoroethoxy)-; 3-(Trifluoroethoxy)picolinic acid; 3-(2,2,2-Trifluoroethoxy)-2-pyridinecarboxylic acid; 3-TFE-Picolinic Acid; 3-(Trifluoroethoxy)pyridine-2-carboxylic acid; 3-(2,2,2-Trifluoroethoxy)picolinic acid; 3-TFE-PCA
EINECS	Contact for details

Quality Control

Our 3-(2,2,2-Trifluoroethoxy)Pyridine-2-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for research and scale-up. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.