Description

17-(o-tert-Butyldimethylsilyl-1-Propynyl-3-Hydroxy)-6β,7β:15β,16β-Dimethyleneandrostane-3β,5β,17β-Triol CAS NO 1248589-64-1 is a highly functionalized androstane derivative, serving as a critical advanced pharmaceutical intermediate in modern synthetic chemistry. Its complex structure, featuring multiple hydroxyl groups and a protected alkyne moiety, makes it an essential building block for the research and development of novel steroid-based therapeutics. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors for the synthesis of complex molecules targeting endocrine and metabolic pathways.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel steroid hormone analogs and receptor modulators.
• Drug Discovery Research: Used in medicinal chemistry programs to explore structure-activity relationships (SAR) for new therapeutic candidates.
• Process Chemistry Development: Serves as a standard or starting material for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Biochemical Research: Employed in studies investigating steroid biosynthesis, metabolism, and enzyme inhibition.
• Reference Standard: Used as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	17-(o-tert-Butyldimethylsilyl-1-Propynyl-3-Hydroxy)-6β,7β:15β,16β-Dimethyleneandrostane-3β,5β,17β-Triol
CAS No.	1248589-64-1
Molecular Formula	C31H50O4Si
Molecular Weight	514.81 g/mol
Synonyms	17-[(tert-Butyldimethylsilyl)oxy]-1-propynyl-3-hydroxy-6β,7β:15β,16β-dimethyleneandrostane-3β,5β,17β-triol; 6β,7β:15β,16β-Dimethylene-3β,5β,17β-trihydroxy-17-[(tert-butyldimethylsilyl)oxy]-1-propynyl-androstane; TBDMS-protected androstane triol alkyne; Androstane derivative with TBDMS and propynyl groups; Steroid intermediate CAS 1248589-64-1
EINECS	Contact for details

Quality Control

Every batch of our 17-(o-tert-Butyldimethylsilyl-1-Propynyl-3-Hydroxy)-6β,7β:15β,16β-Dimethyleneandrostane-3β,5β,17β-Triol is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for each lot. Our quality commitment aligns with the expectations for advanced pharmaceutical intermediates, supporting your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and may be sensitive to fluoride/strong alkali. Keep the container tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.