Description

Ethyl 2-(2-Chlorophenyl)-2,2-Difluoroacetate is a high-purity fluorinated organic building block essential for advanced chemical synthesis. This compound serves as a critical intermediate in the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors, where the introduction of fluorine atoms is a key strategy for modulating biological activity and stability. Its precise structure makes it invaluable for researchers and process chemists engaged in the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, especially those targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides, where the difluoroacetate moiety contributes to enhanced efficacy and environmental profile.
• Material Science Precursor: Serves as a building block for specialty polymers and liquid crystals that require specific fluorinated aromatic components.
• Organic Synthesis Reagent: Employed in cross-coupling reactions and as an electrophile in nucleophilic substitution reactions to construct complex molecular architectures.
• Fluorine Chemistry Research: An important compound for academic and industrial research focused on exploring new fluorination methodologies and reaction pathways.

Basic Information

Product Name	Ethyl 2-(2-Chlorophenyl)-2,2-Difluoroacetate
CAS No.	1248075-48-0
Molecular Formula	C10H9ClF2O2
Molecular Weight	234.63 g/mol
Synonyms	Ethyl 2,2-Difluoro-2-(2-chlorophenyl)acetate; 2-(2-Chlorophenyl)-2,2-difluoroacetic Acid Ethyl Ester; Ethyl α,α-Difluoro-o-chlorophenylacetate; Acetic acid, 2-(2-chlorophenyl)-2,2-difluoro-, ethyl ester; Ethyl (2-chlorophenyl)difluoroacetate; 1248075-48-0; Ethyl 2-(2-Chlorophenyl)-2,2-difluoroethanoate
EINECS	Contact for details

Quality Control

Our Ethyl 2-(2-Chlorophenyl)-2,2-Difluoroacetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports compliance with cGMP guidelines for pharmaceutical intermediates and other regulated applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. This material is moisture-sensitive; ensure containers are kept tightly sealed to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (by GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.