Description

tert-Butyl (5-Methoxy-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-3-Yl)Methylcarbamate is a high-purity, protected boronic ester derivative, a critical building block in modern synthetic chemistry. Its value lies in its role as a key intermediate for constructing complex molecules via cross-coupling reactions, enabling the development of novel active pharmaceutical ingredients (APIs) and advanced materials. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality intermediates for Suzuki-Miyaura and other palladium-catalyzed coupling reactions.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of complex drug candidates, particularly in oncology, neurology, and antiviral research programs.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile boronic ester coupling partner for the formation of carbon-carbon bonds between aromatic and heteroaromatic systems.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, where the pyridine-boronate moiety is a valuable structural component.
• Material Science Research: Employed in the creation of organic electronic materials, such as ligands for catalysts or components for organic light-emitting diodes (OLEDs).
• Chemical Biology & Proteomics: Can be utilized as a building block for synthesizing molecular probes and activity-based protein profiling (ABPP) reagents.
• Library Synthesis for Drug Discovery: Enables the rapid, parallel synthesis of diverse compound libraries for high-throughput screening (HTS) campaigns.

Basic Information

Product Name	tert-Butyl (5-Methoxy-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-3-Yl)Methylcarbamate
CAS No.	1247726-98-2
Molecular Formula	C18H29BN2O5
Molecular Weight	364.25 g/mol
Synonyms	Boc-Protected 3-Aminomethyl-5-Methoxy-4-Pyridineboronic Acid Pinacol Ester; tert-Butyl N-[[5-Methoxy-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-3-Pyridyl]Methyl]Carbamate; 3-((tert-Butoxycarbonyl)Amino)Methyl)-5-Methoxy-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine; 5-Methoxy-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-3-((((2-Methylpropan-2-Yl)Oxy)Carbonyl)Amino)Methyl)Pyridine; 1247726-98-2; Boc-Aminomethyl Pyridine Boronate
EINECS	Contact for details

Quality Control

Our tert-Butyl (5-Methoxy-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-3-Yl)Methylcarbamate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for demanding synthetic applications. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation. Keep the container tightly sealed in a desiccator for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.