Description

α-Amino-4-Fluoro-2-Methyl-Benzeneacetic Acid Methyl Ester is a high-purity, fluorinated amino acid derivative serving as a critical building block in advanced organic synthesis. This compound is valued for its unique molecular architecture, which incorporates both a reactive amino group and a fluorine substituent on an aromatic ring, enabling precise modifications in complex molecular frameworks. It is primarily sought after by research institutions and pharmaceutical developers for the synthesis of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialized fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in fluorinated compound libraries.
• Agrochemical Synthesis: Used as a precursor for creating advanced herbicides, fungicides, and pesticides with enhanced activity and selectivity.
• Peptide Mimetics & Modifications: Enables the incorporation of fluorinated aromatic amino acid analogs into peptide chains for stability and bioactivity studies.
• Ligand & Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in asymmetric catalysis and metal-organic frameworks.
• Material Science Research: Employed in the development of novel fluorinated polymers and advanced organic materials with specific electronic or surface properties.
• Chemical Biology Probes: Useful for labeling and probing biological systems due to the presence of the fluorine atom, which can act as an NMR-active tag.

Basic Information

Product Name	α-Amino-4-Fluoro-2-Methyl-Benzeneacetic Acid Methyl Ester
CAS No.	1247221-05-1
Molecular Formula	C11H12FNO2
Molecular Weight	209.22 g/mol
Synonyms	Methyl 2-Amino-2-(4-fluoro-2-methylphenyl)acetate; 2-(4-Fluoro-2-methylphenyl)glycine methyl ester; 4-Fluoro-2-methyl-DL-phenylglycine methyl ester; (4-Fluoro-2-methylphenyl)glycine methyl ester; Methyl (4-fluoro-2-methylphenyl)glycinate; α-Amino-(4-fluoro-2-methylphenyl)acetic acid methyl ester; DL-4-Fluoro-2-methylphenylglycine methyl ester
EINECS	Contact for details

Quality Control

Our α-Amino-4-Fluoro-2-Methyl-Benzeneacetic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and batch-to-batch consistency for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation and moisture absorption. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.