Description

Ethyl 5-Bromo-3-Hydroxypicolinate is a high-purity, versatile chemical intermediate of significant importance in modern synthetic chemistry. Its value lies in its functionalized picolinate core, which serves as a key building block for constructing complex molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for applications in drug discovery and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging its halogenated heterocyclic structure.
• Ligand and Catalyst Development: Serves as a starting material for creating novel chelating ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of advanced organic materials, such as organic light-emitting diodes (OLEDs) and conductive polymers.
• Chemical Biology Probes: Utilized as a scaffold for developing molecular probes and tags to study biological processes.
• Custom Synthesis and Contract Manufacturing: A key building block offered by fine chemical suppliers for custom synthesis projects requiring brominated hydroxypyridine derivatives.

Basic Information

Product Name	Ethyl 5-Bromo-3-Hydroxypicolinate
CAS No.	1246845-70-4
Molecular Formula	C8H8BrNO3
Molecular Weight	246.06 g/mol
Synonyms	5-Bromo-3-hydroxypyridine-2-carboxylic acid ethyl ester; Ethyl 5-bromo-3-hydroxypyridine-2-carboxylate; 2-Pyridinecarboxylic acid, 5-bromo-3-hydroxy-, ethyl ester; 5-Bromo-3-hydroxy-2-pyridinecarboxylic acid ethyl ester; 1246845-70-4; Ethyl 5-bromo-3-oxo-3,4-dihydro-2-pyridinecarboxylate (tautomer)
EINECS	Contact for details

Quality Control

Every batch of Ethyl 5-Bromo-3-Hydroxypicolinate is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes results from techniques such as HPLC, NMR, and IR spectroscopy. Our quality commitment ensures the material meets the stringent requirements for research and cGMP-grade pharmaceutical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Meets ICH guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.