Description

Risedronic Acid Monoethyl Ester CAS NO 1246815-73-5 is a key synthetic intermediate in the production of risedronate sodium, a bisphosphonate medication used to treat bone disorders. This high-purity building block is critical for ensuring the final active pharmaceutical ingredient (API) meets stringent pharmacopeial standards for safety and efficacy. It is primarily required by pharmaceutical manufacturers and advanced research organizations engaged in osteoporosis treatment development and generic drug formulation.

Application

• Pharmaceutical Intermediate: Primary use as a critical synthetic precursor in the multi-step synthesis of Risedronate Sodium API.
• Generic Drug Manufacturing: Sourcing for cost-effective production of generic bisphosphonate therapies for osteoporosis and Paget's disease.
• Research & Development: Utilized in medicinal chemistry research for developing novel bone resorption inhibitors and optimizing synthetic pathways.
• Process Chemistry: Serves as a standard reference material and a key starting material (KSM) in process scale-up and validation studies.
• Analytical Standard: Used as a certified reference standard in HPLC and LC-MS methods for quality control and impurity profiling of risedronate-based products.

Basic Information

Product Name	Risedronic Acid Monoethyl Ester
CAS No.	1246815-73-5
Molecular Formula	C8H19NO7P2
Molecular Weight	303.19 g/mol
Synonyms	Risedronate Monoethyl Ester; 1-Hydroxy-2-(3-pyridinyl)ethylidene-1,1-bisphosphonic Acid Monoethyl Ester; Monoethyl Risedronate; Risedronic Acid Ethyl Ester; [1-Hydroxy-1-(3-pyridinyl)ethylidene]bis(phosphonic acid) monoethyl ester; Risedronate Intermediate; NE-10790 (Monoethyl Ester); Pyridinyl Bisphosphonate Monoethyl Ester
EINECS	Contact for details

Quality Control

Our Risedronic Acid Monoethyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, related substances, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator to prevent degradation. The storage area should be well-ventilated and separate from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.