Description

tert-Butyl 3'-Amino-1'H-Spiro[Cyclobutane-1,6'-Pyrrolo[3,4-C]Pyrazole]-5'(4'H)-Carboxylate is a high-value, spirocyclic heterocyclic building block designed for advanced pharmaceutical and agrochemical research. This compound matters as a sophisticated molecular scaffold, enabling the rapid synthesis of complex, three-dimensional structures critical for developing novel bioactive molecules. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical industry for drug discovery programs, particularly in kinase inhibitor research and the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel small-molecule drug candidates, especially kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used for scaffold hopping and lead optimization to improve potency, selectivity, and pharmacokinetic properties of drug-like molecules.
• Agrochemical Development: Serves as a precursor in the research and synthesis of new active ingredients for crop protection products.
• Chemical Biology Probes: Utilized to create specialized molecular tools for studying enzyme function and cellular signaling pathways.
• Process Chemistry: Employed in route scouting and scale-up studies for the commercial manufacturing of active pharmaceutical ingredients (APIs).
• Custom Synthesis & Contract Research: A critical starting material for CROs and CDMOs offering bespoke chemical synthesis services.

Basic Information

Item	Details
Product Name	tert-Butyl 3'-Amino-1'H-Spiro[Cyclobutane-1,6'-Pyrrolo[3,4-C]Pyrazole]-5'(4'H)-Carboxylate
CAS No.	1246652-29-8
Molecular Formula	C14H20N4O2
Molecular Weight	276.34 g/mol
Synonyms	tert-Butyl 3-amino-1'H-spiro[cyclobutane-1,6'-pyrrolo[3,4-c]pyrazole]-5'(4'H)-carboxylate; 1'H-Spiro[cyclobutane-1,6'-pyrrolo[3,4-c]pyrazole]-5'(4'H)-carboxylic acid, 3'-amino-, 1,1-dimethylethyl ester; 3'-Amino-1'H-spiro[cyclobutane-1,6'-pyrrolo[3,4-c]pyrazole]-5'(4'H)-carboxylic acid tert-butyl ester; Spiro[cyclobutane-1,6'-pyrrolo[3,4-c]pyrazole] intermediate; 1246652-29-8; tert-Butyl 3-amino-1,4-dihydrospiro[cyclobutane-1,6'-pyrrolo[3,4-c]pyrazole]-5'-carboxylate
EINECS	Contact for details

Quality Control

Our tert-Butyl 3'-Amino-1'H-Spiro[Cyclobutane-1,6'-Pyrrolo[3,4-C]Pyrazole]-5'(4'H)-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support development with custom synthesis and analytical method development to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.