Description

(R)-Methyl 8-Amino-5,6,7,8-Tetrahydronaphthalene-2-Carboxylate Hydrochloride CAS NO 1246509-71-6 is a high-purity chiral intermediate featuring a tetralin scaffold with a critical amino and ester functional group. This compound is essential for the synthesis of complex active pharmaceutical ingredients (APIs) and advanced organic molecules, where stereochemical purity is paramount. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of central nervous system (CNS) agents, receptor modulators, and other fine chemicals requiring a rigid, bicyclic framework.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel drug candidates, particularly in neurological and psychiatric therapeutic areas.
• Chemical Research & Development: Used in academic and industrial R&D for exploring new synthetic pathways and creating compound libraries for high-throughput screening.
• Asymmetric Synthesis: Serves as a precursor for catalysts or ligands in stereoselective reactions due to its defined (R)-configuration.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation.
• Agrochemical Synthesis: Potential intermediate in the development of advanced crop protection agents with specific biological activity.
• Material Science Precursor: Can be utilized in the synthesis of specialty polymers or organic electronic materials requiring specific molecular architectures.

Basic Information

Product Name	(R)-Methyl 8-Amino-5,6,7,8-Tetrahydronaphthalene-2-Carboxylate Hydrochloride
CAS No.	1246509-71-6
Molecular Formula	C₁₃H₁₈ClNO₂
Molecular Weight	255.74 g/mol
Synonyms	(R)-Methyl 8-Amino-5,6,7,8-tetrahydro-2-naphthoate Hydrochloride; (R)-8-Amino-5,6,7,8-tetrahydronaphthalene-2-carboxylic Acid Methyl Ester Hydrochloride; (R)-Methyl 8-Amino-1,2,3,4-tetrahydronaphthalene-2-carboxylate Hydrochloride; (R)-ATNC Methyl Ester HCl; (R)-Methyl 2-Carboxy-8-amino-1,2,3,4-tetrahydronaphthalene Hydrochloride; (R)-8-Amino-5,6,7,8-tetrahydro-2-naphthoic Acid Methyl Ester Hydrochloride
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for pharmaceutical intermediates. Each batch is characterized and controlled using advanced analytical techniques including HPLC, GC, NMR, and chiral analysis to confirm identity, purity, and enantiomeric excess. Certificates of Analysis (COA) detailing all specifications are available upon request, supporting your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.