Description

3-((Trimethylsilyl)Ethynyl)-1,5-Naphthyridine is a specialized organosilicon building block featuring a naphthyridine core functionalized with a trimethylsilyl-protected ethynyl group. This compound is of significant value in advanced organic synthesis and pharmaceutical research, serving as a key intermediate for constructing complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for applications such as cross-coupling reactions and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of potential drug candidates, particularly for constructing complex heterocyclic systems.
• Agrochemical Research: Used in the development of new active ingredients for crop protection and pest management.
• Material Science: Serves as a precursor for organic electronic materials, including semiconductors and light-emitting compounds.
• Cross-Coupling Reactions: The protected alkyne moiety is a versatile handle for Sonogashira and other palladium-catalyzed coupling reactions.
• Ligand Synthesis: Used to create novel nitrogen-containing ligands for catalysis and coordination chemistry.
• Academic & Industrial R&D: A valuable reagent for exploratory chemistry and method development in synthetic laboratories.

Basic Information

Product Name	3-((Trimethylsilyl)Ethynyl)-1,5-Naphthyridine
CAS No.	1246088-67-4
Molecular Formula	C13H16N2Si
Molecular Weight	228.37 g/mol
Synonyms	1,5-Naphthyridine, 3-[(trimethylsilyl)ethynyl]-; 3-(2-Trimethylsilylethynyl)-1,5-naphthyridine; 3-Ethynyl-1,5-naphthyridine trimethylsilyl derivative; TMS-Ethynyl-1,5-naphthyridine; (3-(1,5-Naphthyridinyl))ethynyltrimethylsilane; 3-((Trimethylsilyl)ethynyl)-1,5-naphthyridine; CAS 1246088-67-4
EINECS	Contact for details

Quality Control

Our 3-((Trimethylsilyl)Ethynyl)-1,5-Naphthyridine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for demanding research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ISO 9001 quality management standards, and our analytical methods, including HPLC, NMR, and GC-MS, are validated to provide reliable specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.