Description

8-((Trimethylsilyl)Ethynyl)-2,3-Dihydro-[1,4]Dioxino[2,3-B]Pyridine CAS NO 1246088-47-0 is a high-value, functionalized heterocyclic building block featuring a protected ethynyl group. This compound is specifically engineered for advanced organic synthesis, offering a versatile handle for cross-coupling reactions and molecular diversification. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the construction of complex molecules and active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly for central nervous system (CNS) and antiviral therapies.
• Agrochemical Synthesis: Used in the creation of advanced active ingredients for crop protection products, leveraging its unique heterocyclic core.
• Material Science Research: Serves as a precursor for organic electronic materials and functional polymers due to its conjugated ethynyl-silyl moiety.
• Cross-Coupling Reactions: The trimethylsilyl-protected alkyne group is a strategic handle for Sonogashira and other palladium-catalyzed coupling reactions.
• Ligand and Catalyst Development: Employed in the synthesis of novel chelating ligands and organometallic catalysts for asymmetric synthesis.
• Chemical Biology Probes: Utilized as a building block for creating labeled compounds and molecular probes for biological target identification.

Basic Information

Product Name	8-((Trimethylsilyl)Ethynyl)-2,3-Dihydro-[1,4]Dioxino[2,3-B]Pyridine
CAS No.	1246088-47-0
Molecular Formula	C14H19NO2Si
Molecular Weight	261.39 g/mol
Synonyms	8-((Trimethylsilyl)ethynyl)-2,3-dihydro-[1,4]dioxino[2,3-b]pyridine; 2,3-Dihydro-[1,4]dioxino[2,3-b]pyridine, 8-[(trimethylsilyl)ethynyl]-; 8-(Trimethylsilylethynyl)-2,3-dihydro[1,4]dioxino[2,3-b]pyridine; TMS-Ethynyl Dioxinopyridine; 8-(TMS-ethynyl)-2,3-dihydro-1,4-dioxino[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our production of 8-((Trimethylsilyl)Ethynyl)-2,3-Dihydro-[1,4]Dioxino[2,3-B]Pyridine adheres to stringent quality management protocols. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and structural identity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to guarantee traceability and batch-to-batch consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.