Description

1-(6-Chloro-5-Fluoropyridin-3-Yl)-2,2,2-Trifluoroethanone is a high-value trifluoromethyl ketone building block, a key intermediate in modern synthetic chemistry. Its precise molecular architecture, featuring a halogenated pyridine ring and a reactive ketone group, makes it indispensable for constructing complex molecules with enhanced properties. This compound is primarily sought after by pharmaceutical and agrochemical R&D teams for the synthesis of novel active ingredients, where it serves as a critical precursor.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of drugs targeting the central nervous system and anti-infective agents.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, insecticides, and fungicides, where the fluorine and chlorine atoms contribute to biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for developing specialty polymers, liquid crystals, and organic electronic materials that require specific fluorinated components.
• Chemical Biology & Proteomics: Employed in the design and synthesis of chemical probes and enzyme inhibitors for target identification and validation studies.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Product Name	1-(6-Chloro-5-Fluoropyridin-3-Yl)-2,2,2-Trifluoroethanone
CAS No.	1245915-43-8
Molecular Formula	C7H2ClF4NO
Molecular Weight	227.54 g/mol
Synonyms	1-(6-Chloro-5-fluoropyridin-3-yl)-2,2,2-trifluoroethanone; 1-(6-Chloro-5-fluoro-3-pyridinyl)-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-(6-chloro-5-fluoropyridin-3-yl)ethanone; 6-Chloro-5-fluoro-3-(2,2,2-trifluoroacetyl)pyridine; 3-(Trifluoroacetyl)-6-chloro-5-fluoropyridine; 1245915-43-8; CAS 1245915-43-8
EINECS	Contact for details

Quality Control

Our 1-(6-Chloro-5-Fluoropyridin-3-Yl)-2,2,2-Trifluoroethanone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.