Description

3-Bromo-5-Fluoro-2-(Trifluoromethyl)Pyridine is a high-value, multi-functional halogenated pyridine derivative serving as a critical building block in advanced organic synthesis. Its unique molecular architecture, featuring bromine, fluorine, and a trifluoromethyl group on the pyridine ring, makes it an indispensable intermediate for creating complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine and trifluoromethyl groups enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a building block for synthesizing specialty chemicals, ligands for catalysis, and functional materials like liquid crystals and organic semiconductors.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Fluorinated Compound Library: A valuable reagent for medicinal chemistry teams building diverse compound libraries to explore structure-activity relationships (SAR).

Basic Information

Product Name	3-Bromo-5-Fluoro-2-(Trifluoromethyl)Pyridine
CAS No.	1245914-35-5
Molecular Formula	C7H2BrF4N
Molecular Weight	255.99 g/mol
Synonyms	2-(Trifluoromethyl)-3-bromo-5-fluoropyridine; 3-Bromo-5-fluoro-2-trifluoromethylpyridine; 5-Fluoro-3-bromo-2-(trifluoromethyl)pyridine; Pyridine, 3-bromo-5-fluoro-2-(trifluoromethyl)-; 1245914-35-5
EINECS	Contact for details

Quality Control

Our 3-Bromo-5-Fluoro-2-(Trifluoromethyl)Pyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flames. This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified for high-purity grades.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (GC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.