Description

Propargyl-Peg5-T-Butyl Ester is a specialized bifunctional PEG derivative featuring a terminal propargyl group and a tert-butyl ester. This compound is a crucial intermediate for advanced bioconjugation and click chemistry applications, enabling the precise modification of biomolecules and polymers. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for drug delivery system development, polymer synthesis, and surface functionalization.

Application

• Bioconjugation Linker: Acts as a key spacer and linker for attaching drugs, dyes, or targeting moieties to antibodies, proteins, or peptides via copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry.
• Polymer & Dendrimer Synthesis: Serves as a functional monomer or terminating agent for creating hydrophilic, biodegradable, and functionalized PEG-based polymers and dendrimers.
• Drug Delivery Systems: Used in the design and synthesis of prodrugs and advanced nanocarriers like micelles and liposomes to improve drug solubility, stability, and targeted release.
• Surface Modification: Enables the functionalization of nanoparticles, biosensors, and diagnostic assay platforms to enhance biocompatibility and introduce specific reactive handles.
• Proteomics & Biomaterial Research: Facilitates the study of protein interactions and the development of novel hydrogels and scaffolds for tissue engineering.
• Chemical Biology Tool: Employed in activity-based protein profiling (ABPP) and the development of chemical probes to investigate biological pathways.

Basic Information

Product Name	Propargyl-Peg5-T-Butyl Ester
CAS No.	1245823-50-0
Molecular Formula	C22H40O9
Molecular Weight	448.55 g/mol
Synonyms	Propargyl-PEG5-t-butyl ester; 2,5,8,11,14-Pentaoxaheptadec-16-ynoic acid, 17-tert-butyl ester; tert-Butyl-PEG5-propargyl; Propargyl-PEG5-OtBu; Propargyl-PEG5-tBu ester; Propargyl terminated PEG5 t-butyl ester; 17-(tert-Butoxy)-2,5,8,11,14-pentaoxaheptadec-16-yn-1-oic acid; Alkyne-PEG5-t-butyl ester
EINECS	Contact for details

Quality Control

Our Propargyl-Peg5-T-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for sensitive research and production applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.