Description

6-Oxa-1-Aza-Spiro[3,3]Heptane-1-Carboxylic Acid tert-Butyl Ester is a high-value, protected bicyclic amino acid derivative that serves as a critical building block in advanced organic synthesis. Its unique spirocyclic structure, featuring both oxygen and nitrogen heteroatoms, provides a rigid scaffold for constructing complex molecules with precise stereochemistry. This compound is primarily sought after by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, where it functions as a key intermediate in medicinal chemistry and process optimization.

Application

• Pharmaceutical Intermediate: A versatile building block for synthesizing novel drug candidates, particularly in protease inhibitor and central nervous system (CNS) therapeutic research.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides, leveraging its heterocyclic core for bioactivity.
• Peptidomimetics & Constrained Peptides: The spirocyclic framework is ideal for introducing conformational constraints into peptide backbones, enhancing stability and receptor selectivity.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Probes: Employed in the synthesis of tool compounds for studying enzyme function and biological pathways.
• Material Science Research: Potential monomer for creating novel polymers with specific thermal or mechanical properties.

Basic Information

Product Name	6-Oxa-1-Aza-Spiro[3,3]Heptane-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1245816-27-6
Molecular Formula	C9H15NO3
Molecular Weight	185.22 g/mol
Synonyms	tert-Butyl 6-oxa-1-azaspiro[3.3]heptane-1-carboxylate; 1-(tert-Butoxycarbonyl)-6-oxa-1-azaspiro[3.3]heptane; 1-Boc-6-oxa-1-azaspiro[3.3]heptane; 6-Oxa-1-azaspiro[3.3]heptane-1-carboxylic acid 1,1-dimethylethyl ester; Bicyclic amino acid tert-butyl ester; Spirocyclic amino ester; 1-N-Boc-6-oxa-1-azaspiro[3.3]heptane
EINECS	Contact for details

Quality Control

Our production of 6-Oxa-1-Aza-Spiro[3,3]Heptane-1-Carboxylic Acid tert-Butyl Ester adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment. Our quality system is designed to support cGMP and ISO standards for pharmaceutical and fine chemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed under an inert atmosphere to prevent moisture absorption and degradation. For long-term storage, consider refrigeration at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.