Description

2-Fluoro-6-p-Tolylpyridine is a high-value fluorinated pyridine derivative, a key building block in advanced organic synthesis. This compound matters for its role as a versatile intermediate in the development of pharmaceuticals and agrochemicals, where its unique fluorine-substituted aromatic system can significantly alter biological activity and metabolic stability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides, fungicides, and insecticides, leveraging the fluorine atom for enhanced efficacy and environmental profile.
• Ligand and Catalyst Development: Employed in organometallic chemistry to create novel ligands for catalytic systems used in cross-coupling and other transformative reactions.
• Material Science Research: Acts as a monomer or functionalizing agent in the development of advanced polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.

Basic Information

Product Name	2-Fluoro-6-p-Tolylpyridine
CAS No.	1245646-59-6
Molecular Formula	C₁₂H₁₀FN
Molecular Weight	187.21 g/mol
Synonyms	2-Fluoro-6-(4-methylphenyl)pyridine; 6-(4-Methylphenyl)-2-fluoropyridine; 2-Fluoro-6-p-tolylpyridine; 2-Fluoro-6-(p-tolyl)pyridine; 2-Fluoro-6-(4-tolyl)pyridine; p-Tolyl-2-fluoropyridine; 4-Methylphenyl-2-fluoropyridine
EINECS	Contact for details

Quality Control

Our 2-Fluoro-6-p-Tolylpyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis stages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. Handle and store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.