Description

tert-Butyl 7-Cyano-8-Oxo-5-Azaspiro[3.4]Octane-5-Carboxylate is a high-value, advanced pharmaceutical intermediate featuring a unique spirocyclic and cyano-substituted lactam structure. This compound serves as a critical building block in modern medicinal chemistry, enabling the synthesis of novel, complex active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of innovative therapeutics, particularly in areas such as oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A key synthetic precursor for the development of novel small-molecule drug candidates.
• Protease Inhibitor Synthesis: Used in the construction of complex molecular scaffolds targeting various protease enzymes.
• Kinase Inhibitor Research: Serves as a core fragment in the discovery and optimization of kinase inhibitor libraries.
• Chemical Biology Probes: Employed in the synthesis of specialized probes for studying enzyme function and biological pathways.
• Process Chemistry & Scale-Up: Supports route scouting and optimization for the commercial manufacturing of target APIs.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.

Basic Information

Product Name	tert-Butyl 7-Cyano-8-Oxo-5-Azaspiro[3.4]Octane-5-Carboxylate
CAS No.	1245645-96-8
Molecular Formula	C13H18N2O3
Molecular Weight	250.30 g/mol
Synonyms	5-Azaspiro[3.4]octane-5-carboxylic acid, 7-cyano-8-oxo-, 1,1-dimethylethyl ester; 7-Cyano-8-oxo-5-azaspiro[3.4]octane-5-carboxylic acid tert-butyl ester; tert-Butyl 7-cyano-8-oxo-5-azaspiro[3.4]octane-5-carboxylate; Boc-7-cyano-8-oxo-5-azaspiro[3.4]octane; 1245645-96-8; tert-Butyl 7-cyano-8-oxo-5-azaspiro[3.4]octane-5-carboxylate
EINECS	Contact for details

Quality Control

Our tert-Butyl 7-Cyano-8-Oxo-5-Azaspiro[3.4]Octane-5-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, confirming compliance with client specifications and supporting regulatory filings for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.