Description

5-Chloro-1H-Pyrazolo[3,4-B]Pyridin-3-Amine is a high-purity heterocyclic organic compound that serves as a critical building block in advanced pharmaceutical research and development. Its value lies in its unique fused pyrazolopyridine scaffold, which is a privileged structure for designing potent and selective bioactive molecules. This intermediate is essential for medicinal chemists and R&D teams in the pharmaceutical and agrochemical industries who are developing new therapeutic agents and crop protection solutions.

Application

• Pharmaceutical Intermediate: A key synthon for the development of kinase inhibitors, particularly for oncology and anti-inflammatory drug discovery programs.
• Agrochemical Research: Used in the synthesis of novel active ingredients for crop protection and pest management.
• Chemical Biology Probe Development: Serves as a core structure for creating tool compounds to study biological pathways and target validation.
• Material Science Precursor: Potential use in the synthesis of organic electronic materials and ligands for catalysis.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting outsourced drug discovery and development.

Basic Information

Product Name	5-Chloro-1H-Pyrazolo[3,4-B]Pyridin-3-Amine
CAS No.	1245643-75-7
Molecular Formula	C6H5ClN4
Molecular Weight	168.58 g/mol
Synonyms	5-Chloro-1H-pyrazolo[3,4-b]pyridin-3-amine; 3-Amino-5-chloro-1H-pyrazolo[3,4-b]pyridine; 5-Chloro-3-amino-1H-pyrazolo[3,4-b]pyridine; 1245643-75-7; 5-Chloro-1H-pyrazolo[3,4-b]pyridin-3-ylamine; 5-Chloro-1H-pyrazolo[3,4-b]pyridin-3-amine (ACI); 5-Chloro-1H-pyrazolo[3,4-b]pyridine-3-amine
EINECS	Contact for details

Quality Control

Our 5-Chloro-1H-Pyrazolo[3,4-B]Pyridin-3-Amine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing key parameters such as assay and impurity profiles. Our quality commitment supports compliance with cGMP and ISO standards for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container sealed to protect from moisture. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.