Description

6-Bromo-2,3,5,6-Tetrahydrospiro[Indene-2,4-Pyran]-1(3H)-One is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic molecular architecture. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system and metabolic disorders. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of novel therapeutic agents.
• Drug Discovery Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry: Serves as a crucial building block in the scale-up and route development for new APIs.
• Chemical Synthesis: Employed in organic synthesis to construct complex spirocyclic and heterocyclic frameworks.
• Academic Research: Utilized in university and institutional labs for methodological studies in synthetic organic chemistry.

Basic Information

Product Name	6-Bromo-2,3,5,6-Tetrahydrospiro[Indene-2,4-Pyran]-1(3H)-One
CAS No.	1245514-78-6
Molecular Formula	C₁₃H₁₁BrO₂
Molecular Weight	279.13 g/mol
Synonyms	6-Bromo-1,3-dihydrospiro[indene-2,4'-pyran]-1-one; 6-Bromospiro[indene-2,4'-pyran]-1(3H)-one; 6-Bromo-2,3,5,6-tetrahydrospiro[indene-2,4-pyran]-1(3H)-one; 1245514-78-6; Spiro[indene-2,4'-pyran]-1(3H)-one, 6-bromo-2,3,5,6-tetrahydro-; 6-Bromo-2,3,5,6-tetrahydro-1H-spiro[indene-2,4'-pyran]-1-one
EINECS	Contact for details

Quality Control

Our 6-Bromo-2,3,5,6-Tetrahydrospiro[Indene-2,4-Pyran]-1(3H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specifications and test results to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.