Description

Methyl 4-Amino-1-(4-Chlorobenzyl)Piperidine-4-Carboxylate Hydrochloride is a high-purity, pharmaceutically relevant piperidine derivative supplied as a hydrochloride salt. This compound serves as a critical advanced pharmaceutical intermediate (API intermediate) in the synthesis of complex active ingredients. It is primarily utilized by research organizations and fine chemical manufacturers engaged in drug discovery and development, particularly for central nervous system (CNS) and other therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those targeting neurological receptors.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Fine Chemical Synthesis: Employed in multi-step organic syntheses to introduce the 4-amino piperidine-4-carboxylate moiety into complex molecular architectures.
• Contract Manufacturing (CMO): Supplied to contract development and manufacturing organizations (CDMOs) for scale-up and cGMP production of active pharmaceutical ingredients (APIs).
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	Methyl 4-Amino-1-(4-Chlorobenzyl)Piperidine-4-Carboxylate Hydrochloride
CAS No.	1244949-76-5
Molecular Formula	C15H22ClN2O2 • HCl
Molecular Weight	335.27 g/mol (Free base: 298.80 g/mol)
Synonyms	1-(4-Chlorobenzyl)-4-(methoxycarbonyl)-4-piperidinamine hydrochloride; Methyl 1-[(4-chlorophenyl)methyl]-4-amino-4-piperidinecarboxylate hydrochloride; 4-Amino-1-(4-chlorobenzyl)piperidine-4-carboxylic acid methyl ester hydrochloride; 4-Piperidinecarboxylic acid, 4-amino-1-[(4-chlorophenyl)methyl]-, methyl ester, hydrochloride; Methyl 4-amino-1-(4-chlorobenzyl)isonipecotate hydrochloride; 1244949-76-5; 1-(4-Chlorobenzyl)-4-(methoxycarbonyl)piperidin-4-amine hydrochloride
EINECS	Contact for details

Quality Control

Our production of Methyl 4-Amino-1-(4-Chlorobenzyl)Piperidine-4-Carboxylate Hydrochloride adheres to stringent in-house quality protocols. Every batch is characterized and tested using advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support development and commercial projects with material suitable for research use and can discuss cGMP-grade manufacturing upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.